The Fear Circuit Revisited: Contributions of the Basal Amygdala Nuclei to Conditioned Fear
نویسندگان
چکیده
منابع مشابه
The fear circuit revisited: contributions of the basal amygdala nuclei to conditioned fear.
The lateral nucleus (LA) is the input station of the amygdala for information about conditioned stimuli (CSs), whereas the medial sector of the central nucleus (CeM) is the output region that contributes most amygdala projections to brainstem fear effectors. However, there are no direct links between LA and CeM. As the main target of LA and with its strong projection to CeM, the basomedial amyg...
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It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST), the two major subdivisions of the central extended amygdala. Early versions of this hypothesis remain highly influential and have been incorporated into the National Institute of Mental Health Rese...
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Although the role of the amygdala in acquisition of conditioned fear is well established, there is debate concerning the intra-amygdala circuits involved. The lateral nucleus of the amygdala (LA) is thought to be an essential site of plasticity in fear conditioning. The LA has both direct and indirect [via the basal nuclei; basal amygdala (BA)] projections to the central nucleus (Ce) of the amy...
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freezing and FPS (Walker and Davis, 1997; see also Since the publication of Weiskrantz’ seminal paper, widely Davis, 1997, for a review of much of the relevant literainterpreted as suggesting that amygdala lesions impair ture). Therefore, critical additional evidence must be the formation of stimulus–reinforcement associations provided to exclude the very real possibility that the (Weiskrantz, ...
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IMPORTANCE Obsessive-compulsive disorder (OCD) may be characterized by impaired self-regulation and behavioral inhibition. Elevated fear and anxiety are common characteristics of this disorder. The neurobiology of fear regulation and consolidation of safety memories have not been examined in this patient population. OBJECTIVE To examine the psychophysiological and neurobiological correlates o...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2011
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3410-11.2011